子供の頃から音楽に特別な興味を持つ。彼はジョージア州サヴァンナで15年生活し、銀行員として働いたが、同時に本当に愛すること――音楽も続けていた。F. I. Abelのもとで学び、始めていた作曲の技術も向上させた。彼の初期の作品は、フィラデルフィアやボストンの多くの出版社には断られ、ようやく1822年に、彼の生地であるマサチューセッツ州ボストンのヘンデル・ハイドン協会で認めてもらえた。しかし、その作品集にはMasonの名前もつけられなかった。
Masonはボストンでアメリカの公立学校の最初の音楽教師になった。1833年、彼はボストン音楽アカデミーの共同創設者となり,1838年にはボストン学校制度全体の音楽監督者となった。Lowell Masonは1,600曲以上の宗教音楽を書き、しばしばアメリカの教会音楽の父と呼ばれる。彼の著作は以下のようなものを含む。 Church Psalmody, with David Greene (Boston, Massachusetts: Perkins & Marvin, 1831) Manual of Christian Psalmody, with Rufus Babcock & David Greene (Boston, Massachusetts: Perkins & Marvin, 1832) The Choir, or Union Collection of Church Music, 1832 Union Hymns, with Rufus Babcock, Jr. (Boston, Massachusetts: 1834) The Sacred Harp or Eclectic Harmony, with his brother Timothy B. Mason (Cincinnati, Ohio: Truman & Smith, 1835) Spiritual Songs for Social Worship, with Thomas Hastings (Utica, New York: Gardiner Tracy, 1835) The Sacred Harp or Eclectic Harmony, with Timothy B. Mason (Cincinnati, Ohio: Truman & Smith, 1835) Sabbath School Harp (Boston, Massachusetts: Massachusetts Sabbath School Society, 1836) The Sabbath School Harp, second edition (Boston, Massachusetts: Massachusetts Sabbath School Society, 1837) The Modern Psalmist (Boston, Massachusetts: John Hubbard Wilkins & Richard B. Carter, 1839) Sabbath School Songs (Boston, Massachusetts: Massachusetts Sabbath School Society, 1841) Chapel Hymns (Boston, Massachusetts: T. R. Marvin, 1842) Church Psalmody (Boston, Massachusetts: T. R. Marvin, 1843) The American Sabbath School Singing Book (Philadelphia, Pennsylvania: Perkins & Purves, 1843) Carmina Sacra: or Boston Collection of Church Music (Boston, Massachusetts: John Hubbard Wilkins & Richard B. Carter, 1844) The Psaltery (Boston, Massachusetts: Wilkins, Carter & Company, 1845) Song-Book of the School Room, with George James (Boston, Massachusetts: Wilkins, Carter & Company, 1847) The National Psalmist (Boston, Massachusetts: Tappan, Whittemore & Mason, 1848) Cantica Laudis: or The American Book of Church Music, with George Webb (New York: Mason & Law, 1850) Musical Letters from Abroad (Boston, Massachusetts: Oliver Ditson, 1853) The New Carmina Sacra (Boston, Massachusetts: Rice and Kendall, 1853) The Hallelujah: A Book for the Service of Song in the House of the Lord (New York: Mason Brothers, circa 1854) The Sabbath Hymn and Tune Book, with Edwards A. Park & Austin Phelps (New York: Mason Brothers, 1859) The Sabbath School Hymn and Tune Book, with Edward A. Park, Austin Phelps & Francis Wayland (New York: Mason Brothers, 1860) The Diapason: A Collection of Church Music, edited by George Root (New York: Mason Brothers, 1860) Asaph: or, The Choir Book (New York: Mason Brothers, 1861
作品を含む出版物: Colles, Volume 3, p. 341 Findagrave, accessed 2 Jan 2018 Hall, pp. 17-19 Hughes, pp. 484-85 Jones, pp. 91-92 McCutchan, pp. 42-44 Metcalf, pp. 211-18 Nutter, p. 461 Randel, pp. 561-62 Stulken, p. 352 Wikipedia, accessed 20 Nov 2016
作曲作品: Admah Adwell Ae Ain Alvan Amboy Antioch Anvern Apheka Arfau Ariel Arnville Ashwell Ayrton Azmon Baim Ballington Bealoth Beethoven Belville Bethany Boylston Bradnor Brattle Street Brentford Brest Capello Carnes Chimes Corydon Coventry Cowper Cyprus Dallas Danvers Darien Das Lieben Bringt Gross Freud Dennis Dort Downs Eden El Paran Eltham Ernan Evan Farnham Ford Frenor Gerar Gregorian Haddam Hamburg Hanwell Hartel (similar to Meribah) Harwell Harwich Hebron Hendon Henley Hermon Highton Illa Ingham Inverness Kane Kimball Laban Langdon Leni Litchfield Lowell Malvern Mendebras Meribah Migdol Missionary Hymn Mond Moriah Mount Vernon Mount Zion Murphy Murray Nain Naomi Nashville Nayton Norwich Oak Oliphant Olivet Olmutz Olney Orrington Ostend Ottawa Ovio Peal Putney Reo Ripley Rockingham Rodman Sabbath Sale Selvin Serug Shalem Shawmut Snowfield Star of Peace Timna Trell Upton Ur Uxbridge Ward Watchman Wesley Whiteland Wilbraham Wilmot Work Song Wye Zebulon Zerah